My opinion, I have /etc/prelink.conf and first two lines are saying:
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# prelink.conf autogenerated by env-update; make all changes to
# contents of /etc/env.d directory
So I never modified it. I also have /etc/env.d/60prelink, and my defaults were:
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PRELINK_PATH_MASK=/usr/lib/wine:/usr/lib/valgrind
PRELINK_PATH=""
During first prelinking it print such messages:
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prelink: /usr/lib/transgaming_cedega/winex/bin/wine: Could not find one of the dependencies
So I modified 60prelink:
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PRELINK_PATH_MASK=/usr/lib/wine:/usr/lib/valgrind:/usr/lib/transgaming_cedega/winex/bin
PRELINK_PATH=""
Afterwards I typed env-update and in /etc/prelink.conf was automaticly added this line:
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-b /usr/lib/transgaming_cedega/winex/bin
Look what you have in 60prelink and whether prelink.conf will be changed after env-update.